ABSTRACT

The role of metastasis on the poor prognosis of cancer is undeniably important. For this reason, revealing the role of metastasis and defining the factors contributing to it play a key role in the treatment of cancer. In this review, we aimed to research various genes, markers and factors related to metastasis, the functions of platelets in metastasis, tumor’s ability to dodge the immune system and two different aspects of autophagy in tumor cells. Under the prognosis section, we gave more details on epithelial-mesenchymal transition which has a role on the malignancy and we examined the effect of factors on metastasis. In other two sections, we mentioned that thrombosis and platelets support metastasis, platelets play a role in dodging immune system and there are two opposite mechanisms triggering tumor formation.