ABSTRACT

This retrospective study aims to emphasize clinicopathological data and diagnosis of an uncommon myeloid neoplasm; myeloid sarcoma.

Data of ali patients from 2000-2019 were retrieved from the archives of Trakya University School of Medicine Hematology and Pathology Departments. Patients’ charts were examined retrospectively by collecting data inclu-ding age, gender, anatomic site, history of hematological malignancy, blood count, pathological characteristics and treatments administered.

There were 8 patients; 6 male and 2 female. The median age was 42.5 years (range: 29-69 years). The most prevalently involved sites were skin, lymph node and bone/soft tissue. There were six patients as myeloid sarcoma with preexisting or concurrent acute myeloid leukemia, one patient as de novo and one patient as acute myeloid leukemia with mye-lodysplasia related changes. One of the concurrent acute myeloid leukemia patients was Down syndrome related acute myeloid leukemia with myeloid sarcoma. Immunohistochemically, out of 8 patients, 4 were of myelomonocytic, 2 were of the myelocytic and 2 were of the monocytic differentiation.

Myeloid sarcoma is a tumor mass made up of immature myeloid blasts appearing at an anatomical site other than bone marrow. Taking into account of having a challenging diagnosis, unusual cellular infıltration at any site on a patient especially with a history of acute myeloid leukemia should have myeloid sarcoma in their differential diagnosis.

Keywords: Myeloid sarcoma, acute myeloid leukemia, myeloid neoplasia